BRADLEY C. HYMAN

Emeritus Professor of Biology
Office 1358E Spieth Hall
Phone (951) 827-5911

E-mail: bradley.hyman@ucr.edu

Degree:
Ph.D., University of California, Los Angeles, 1980

My research seeks to understand the molecular basis of structural diversity, genetic organization, and mode of replication exhibited by animal mitochondrial DNAs. To this end, I am studying the mitochondrial genomes from several phylogenetically separated nematodes. My recent studies have focused upon mitochondrial DNA recombination, gene amplification and rearrangements in mermithid nematodes, obligate invertebrate parasites, and in the plant parasitic root knot nematode Meloidogyne. These mitochondrial DNAs appear to undergo "real-time" rearrangement, thereby generating a large array of polymorphic mitochondrial genome forms. We are evaluating the utility of these mitochondrial DNA types as useful markers to study population dynamics and cytoplasmic gene flow.

Dr.  Hyman participates in the Genetics, Genomics, and Bioinformatics Ph.D. Program and is a past Director. He also is a member of the Cell, Molecular, and Developmental Biology Graduate Program. He currently serves as the Faculty Director for UCR's CaTEACH-Science/Mathematics Initiative, designed to encourage mathematics and sciences students to pursue careers in teaching. He also participates and participates in IDEA, the UCR Institute for the Development of Educational Applications. He is a past Editor-in-Chief of the Journal of Nematology. Dr. Hyman is the Chair of UCR's Academy of Distinguished Teachers.

Some Representative Publications....

• Lewis, S.C., P. Joers, S. Wilcox, J. D. Griffith, H. T. Jacobs, and B. C. Hyman. 2015. A rolling circle replication mechanism produces multimeric lariats of mitochondrial DNA in Caernorhabditis elegans. PLoS Genetics, February 18, 2015 DOI: 10.1371/journal.pgen.1004985 .
• Belaich, M., D. Buldain, D. Ghiringhelli, B.C. Hyman, M. Micieli, and M. Achinelly. 2015. Nucleotide sequence differentiation of Argentine isolates of the mosquito parasitic nematode Strelkovimermis (Nematode; Mermithidae). Journal of Vector Ecology 40:415-418.
• Pérez-Pacheco, R., E.G. Platzer, D. Woodward, and B. C. Hyman. 2014. Bioassays for comparative infectivity of mermithid nematodes (Romanomermis iyengari, Romanomermis culicivorax, and Strelkovimermis spiculatus) for culicine mosquito larvae. Biological Control 80:113-118.
• Hyman,B. C., S. C. Lewis, S. Tang, and Z. Wu. 2011. Rampant gene rearrangement and haplotype hypervariation among nematode mitochondrial genomes. Genetica 139:611-615.
• Poinar, G. Jr., S. C. Lewis, N. T. Hagen and B. C. Hyman. 2011. Systematic affinity of the sea urchin parasite, Echinomermella matsi Jones & Hagen (Enoplida: Echinomermellida; Echinomermellidae). Nematology 13:747-753.
• Brady, B.S., B.C. Hyman and C.J. Lovatt. 2010. Regulation of CPSase, ACTase, and OCTase Genes in Medicago truncatula: Implications for carbamoylphosphate synthesis and allocation to pyrimidine and arginine de novo biosynthesis. Gene 462:18-25.
• Peat, S.M., B.C. Hyman, and B. J. Adams. 2009. Phylogenetics and Population Genetics of Entomopathogenic and Insect-parasitic Nematodes. In Insect Pathogens: Molecular Approaches and Techniques. S. P. Stock, J. Vandenberg, N. Boemare and I. Glazer, Eds. CABI International, Cambridge, MA. p.164-192.
• Tang, S. and B. C. Hyman.  2007. Mitochondrial genome haplotype hypervariation within the isopod parasitic nematode Thaumamermis cosgrovei.  Genetics 176:1139-1150.
• Poinar, G. O. Jr., S. D. Porter, S. Tang and B. C. Hyman. 2007. Allomermis solenopsii sp. new. (Mermithidae: Nematoda) parasitizing the fire ant Solenopsis invicta Buren (Hymenoptera: Formicidae) in Argentina. Systematic Parasitology 68:115-128.
• Tang, S. and B. C. Hyman. 2005. Rolling circle amplification of complete nematode mitochondrial genomes. Journal of Nematology 37:236-241. (Featured cover article).
• Chen, P., P. A. Roberts, A. E. Metcalf, and B. C. Hyman. 2003. Nucleotide substitution patterning within the Meloidogyne D3 region and its evolutionary implications. Journal of Nematology 35:404-410.
• Hyman, B.C. 2003. Nucleic Acids and Proteins: Modern Linguistics for the Genomics and Bioinformatics Era. Pp. 5-23 in S. A. Krawetz and D. D. Womble, Eds. Introduction to Bioinformatics. Humana Press.
• Metcalf, A. E., L. Nunney, and B. C. Hyman. 2001. Geographic patterns of genetic differentiation within the restricted range of the endangered Stephens' kangaroo rat, Dipodomys stephensi.  Evolution 55:1233-1244.
• Zhou, Z., C.J.  Lovatt, A.E.  Metcalf, and B.C.  Hyman (2000).  Alfalfa (Medicago sativa) carbamoylphosphate synthetase gene structure records the deep lineage of plants.  Gene 243:105-114. 
• Lunt, D.  H., L.  E.  Whipple and B.  C.  Hyman (1998).  Mitochondrial DNA VNTRs: Utility and problems in molecular ecology.  Molecular Ecology 7:1441-1455. 
• Lunt, D.H.  and B.C.  Hyman.  (1997).  Animal mitochondrial DNA recombination.  Nature 387:247. 
• Ibrahim, S., J.  Baldwin, P.  Roberts and B.  Hyman (1997).  Genetic variability in Nacobbus aberrans: An approach towards taxonomic resolution.  Journal of Nematology 29:241-249. 
• Hyman, B.  C.  and L.  E.  Whipple.  (1996).  Application of mitochondrial DNA polymorphism to Meloidogyne molecular population biology.  Journal of Nematology 28:268-276
• Hyman, B.  C.  and J.  L.  B.  Azevedo (1996) .  Similar evolutionary patterning among repeated and single copy nematode mitochondrial genes.  Molecular Biology and Evolution 13:221-232. 
• Demers, D., A.  E.  Metcalf, P.  Talbot and B.  C.  Hyman (1996).  Multiple lobster tubulin isoforms are encoded by a simple gene family.  Gene 171:185-191. 
• Hyman, B.  C.  (1996).  Molecular systematics and population biology of phytonematodes: Some unifying principles.  Fundamental and Applied Nematology 19:309-313. 

Recent Teaching....

• Biology 5A, Introduction to Cell and Molecular Biology
• Biology 107A, Molecular Biology
• Biology 107B, Advanced Molecular Biology
• Biology 109, Laboratory in Molecular Biology
• Biology 281, Seminar in Cell Development, Structure, and Function