Experimental Evolution Publications by Ted Garland: Artificial Selection for High Voluntary Wheel-Running Behavior in House Mice
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Inquiry-Based Middle School Lesson Plan -- "Born to Run: Artificial Selection Lab"Table
of Contents for:
Garland, T., Jr., and M. R. Rose, eds. 2009. Experimental
evolution: concepts, methods, and applications
of selection experiments. University of California Press,
Berkeley, California. xvii + 730 pages.
***** PDFs of the chapters are available from the authors or from me. *****
Entire Book is Available Here as a fairly large PDF file
Network for Experimental Research on Evolution (NERE)
Intercampus Research Program on Experimental Evolution (UCIRPEE) (previous incarnation of NERE)
Videos on the High Runner Mice:
Video of Mice Running on Wheel (Girard et al. 2001)
Garland Public Lecture on "Born to Run: Evolution of Hyperactivity in Mice" 29 Oct. 2009
Dr. Garland discussing "How to run far: Multiple solutions and sex-specific responses to selective breeding ..." PDF file
Dr. Garland discussing the High Runner mice in a short video
YouTube Channel
Stories on the High Runner Mice as Exercise Addicts:
"Fit and Dim?" by Lee Dye for ABCNews.com
ScienCentral.com
Sciencemag.org or
view PDF file here
Holden, C. 2001.‘Behavioral ’Addictions:
Do They Exist? Science 294:980-982.
http://www.news.wisc.edu/9208.html
Other Stories on the High Runner Mice:
Focus
on "Lifelong voluntary exercise in the mouse prevents age-related alterations
in gene expression in the heart"
"Running mice are leaner" by Henry Gee for Nature
"Fitness
fanatic or couch potato? Blame your DNA" by Christie Aschwanden for the Los
Angeles Times
Sports Illustrated article
on "Sports Genes" by David Epstein -- mice are mentioned on last page
Ted Garland quoted in The Sports Gene: Inside the Science of Extraordinary Athletic Performance (2013) by David Epstein
Textbook Features on our Research with the High
Runner Mice:
Two-page Box
on the mouse selection experiment in 2006 Comparative Physiology text by Moyes and Schulte
Two-pages on the mouse selection experiment in 2014 Evolutionary Analysis text by Herron and Freeman (with contributions by Hodin, Miner, Sidor)
Page discussing a selection experiment on mouse maternal aggression by Stephen Gammie that Ted helped with in 2014 Evolutionary Analysis text by Herron and Freeman
53.
Swallow, J. G., T. Garland, Jr., P. A. Carter, W.-Z. Zhan, and G.
C. Sieck. 1998.
Effects of voluntary
activity and genetic selection on aerobic capacity in house mice
(Mus domesticus).
Journal of Applied Physiology 84:69-76. Abstract
[PDF
file]
57.
Swallow, J. G., P. A. Carter, and T. Garland, Jr. 1998. Artificial selection
for increased wheel-running
behavior in house mice.
Behavior Genetics 28:227-237. Abstract
[PDF
file]
58. Krugner-Higby, L., A. Gendron, T. Garland, Jr., P. A.
Carter, J. G. Swallow, and J. J. Lee. 1998.
Eosinophylic polymyositis
in a mouse.
Contemporary
Topics in Laboratory Animal Science 37:94-97. [PDF
file]
62.
Koteja, P., J. G. Swallow, P. A. Carter, and T. Garland, Jr. 1999. Energy cost
of wheel running in
house mice: implications
for coadaptation of locomotion and energy budgets.
Physiological and
Biochemical Zoology 72:238-249. Abstract
[PDF
file]
67.
Swallow, J. G., P. Koteja, P. A. Carter, T. Garland, Jr. 1999. Artificial selection
for increased
wheel-running activity
in house mice results in decreased body mass at maturity.
Journal of Experimental
Biology 202:2513-2520. Abstract
[PDF
file]
68. Koteja, P., T. Garland, Jr., J. K. Sax, J. G. Swallow,
and P. A. Carter. 1999. Behaviour of house
mice artificially selected
for high levels of voluntary wheel running. Animal Behaviour 58:1307-1318.
Abstract
[PDF
file]
69. Zhan, W.-Z.,
J. G. Swallow, T. Garland, Jr., D. N. Proctor, P. A. Carter, and G. C. Sieck.
1999.
Effects of genetic
selection and voluntary activity on the medial gastrocnemius muscle in
house mice. Journal
of Applied Physiology 87:2326-2333. Abstract
[PDF
file]
70.
Rhodes, J. S., P. Koteja, J. G. Swallow, P. A. Carter, and T. Garland, Jr. 2000.
Body temperatures
of house mice artificially
selected for high voluntary wheel-running behavior: repeatability and effect
of genetic selection.
Journal of Thermal Biology 25:391-400. Abstract
[PDF
file]
71. Carter, P. A., J. G. Swallow, Sarah J. Davis, and T.
Garland, Jr. 2000. Nesting behavior of house mice
(Mus domesticus)
selected for increased wheel-running activity.
Behavior Genetics
30:85-94. Abstract
[PDF
file]
74.
Houle-Leroy, P., T. Garland, Jr., J. G. Swallow, and H. Guderley. 2000. Effects
of voluntary activity
and genetic selection
on muscle metabolic capacities in house mice Mus domesticus.
Journal of Applied
Physiology 89:1608-1616. Abstract
[PDF
file]
76. Koteja, P., J. G. Swallow, P. A. Carter, and T. Garland,
Jr. 2000. Individual variation
and repeatability of
maximum cold-induced energy assimilation in house mice.
Acta Theriologica
45:455-470. Abstract
[PDF
file]
77. Koteja, P., and T. Garland, Jr. 2001. Response to R.
Eikelboom. Animal Behaviour 61:F25-F26.
[PDF
file]
[Eikelboom, R. 2001. Bins,
bouts and wheel running speed. Animal Behaviour 61:679-681.]
78. Koteja, P., J. G. Swallow, P. A. Carter, and T. Garland,
Jr. 2001. Maximum cold-induced food
consumption in mice selected
for high locomotor activity: implications for the evolution of endotherm
energy budgets. Journal
of Experimental Biology 204:1177-1190. Abstract
[PDF
file]
83. Swallow, J. G., P. Koteja, P. A. Carter, and T. Garland,
Jr. 2001. Food consumption and body
composition in mice selected
for high wheel-running activity.
Journal of Comparative
Physiology B 171:651-659. Abstract
[PDF
file]
[Gee, Henry. 14 Sept. 1999.
Lifelines: Running mice are leaner mice.
Nature Science
Update. http://www.nature.com/nsu/990916/990916-6.html]
84. Dumke, C. L., J. S. Rhodes, T. Garland, Jr., E. Maslowski,
J. G. Swallow, A.C. Wetter, and
G.
D. Cartee. 2001. Genetic selection of mice for high voluntary wheel-running:
effect on skeletal
muscle glucose uptake. Journal
of Applied Physiology 91:1289-1297. Abstract
[PDF
file]
85. Bronikowski, A. M., P. A. Carter, J. G. Swallow, I.
A. Girard, J. S. Rhodes, and T. Garland, Jr.
2001. Open-field behavior
of house mice selectively bred for high voluntary wheel running.
Behavior Genetics
31:309-316. Abstract
[PDF
file]
86. Rhodes, J. S., G. R. Hosack, I. Girard, A.
E. Kelley, G. S. Mitchell,
and T. Garland, Jr. 2001.
Differential sensitivity
to acute administration of cocaine, GBR 12909, and fluoxetine in mice selectively
bred for hyperactive wheel-running
behavior. Psychopharmacology 158:120-131. Abstract
[PDF
file]
87. Girard, I., M. W. McAleer, J. S. Rhodes, and T. Garland,
Jr. 2001. Selection for high voluntary wheel
running increases intermittency
in house mice (Mus domesticus). [PDF
file]
Journal of Experimental
Biology 204:4311-4320. Movie
See also "In
this issue" pages i-ii.
90. Garland, T., Jr. 2001. Phylogenetic comparison and artificial
selection: two approaches in
evolutionary physiology.
Pages 107-132 in R. C. Roach, P. D. Wagner, and P. H. Hackett, eds.
Hypoxia: From Genes to the
Bedside. Advances in Experimental Biology and Medicine, volume 502.
Kluwer Academic/Plenum Publishers,
New York. [PDF
file]
92. Thomson, S. L., T. Garland, Jr., J. G. Swallow, and
P. A. Carter. 2002. Response of Sod-2 enzyme
activity to selection for
high voluntary wheel running. Heredity 88:52-61. Abstract
[PDF
file]
93. Girard, I., and T. Garland, Jr. 2002. Plasma corticosterone
response to acute and chronic voluntary
exercise in female house
mice. Journal of Applied Physiology 92:1553-1561. [PDF
file]
94. Girard, I., J. G. Swallow, P. A. Carter, P. Koteja,
J. S. Rhodes, and T. Garland, Jr. 2002.
Maternal-care behavior and
life-history traits in house mice (Mus domesticus) artificially
selected for high voluntary
wheel-running activity. Behavioural Processes 57:37-50. [PDF
file]
95. Garland, T., Jr. 2003. Selection experiments: an under-utilized
tool in biomechanics and organismal
biology. Pages 23-56 in V.
L. Bels, J.-P. Gasc, and A. Casinos, eds. Vertebrate Biomechanics and
Evolution. BIOS Scientific
Publishers, Oxford, U.K. [PDF
file]
96. Garland, T., Jr., M.
T. Morgan, J. G. Swallow, J. S. Rhodes, I. Girard, J. G. Belter, and P.
A. Carter.
2002. Evolution of a small-muscle
polymorphism in lines of house mice selected for high activity levels.
Evolution 56:1267-1275.
[PDF
file]
97. Klomberg, K. L.,
T. Garland, Jr., J. G. Swallow, and P. A. Carter. 2002. Dominance, plasma testosterone
levels, and testis size in
mice artificially selected for high activity levels.
Physiology & Behavior
77:27-38. Abstract
[PDF
file]
98.
Bronikowski, A. M., T. J. Morgan, T. Garland Jr., and P. A. Carter. 2002. Antioxidant
gene expression
in active and sedentary house
house mice (Mus domesticus) selected for high voluntary wheel-running
behavior. Genetics
161:1763-1769. [PDF
file]
102.
Houle-Leroy, P., T. Garland, Jr., J. G. Swallow, and H.
Guderley. 2003. Artificial selection for high
activity favors
mighty mini-muscles in house mice. American Journal of Physiology
Regulatory
Integrative Comparative Physiology 284:R433-R443. [PDF
file]
103.
Morgan, T. J., T. Garland, Jr., and P. A. Carter. 2003. Ontogenies in mice selected
for high voluntary
wheel-running
activity. I. Mean ontogenies. Evolution 57:646-657. [PDF
file]
104. Bronikowski, A. M., P. A. Carter, T. J. Morgan, T.
Garland, Jr., N. Ung, T. D. Pugh, R.
Weindruch,
and T.
A. Prolla. 2003. Lifelong voluntary exercise in the mouse prevents age-related
alterations in gene
expression in
the heart. Physiological Genomics 12:129-138. [PDF
file]
[Welle, S., and
S. B. Glueck. 2003. In for the long run: Focus on "Lifelong voluntary exercise
in the mouse
prevents
age-related alterations in gene expression in the heart." Physiological Genomics
12:71-72.]
106.
Rhodes, J. S., and T. Garland, Jr. 2003. Differential sensitivity to acute administration
of Ritalin,
apomorphine,
SCH 23390, and raclopride in mice selectively bred for hyperactive wheel-running
behavior.
Psychopharmacology
167:242-250. [PDF
file]
107.
Morgan, T. J., T. Garland, Jr., B. L. Irwin, J. G. Swallow, and P. A. Carter.
2003. The mode of evolution
of molecular
markers in populations of house mice under artificial selection for locomotor
behavior.
Journal of
Heredity 94:236-242. [PDF
file]
109.
Rhodes, J. S., H. van Praag, S. Jeffrey, I. Girard, G. S. Mitchell,
T. Garland, Jr., and F. H. Gage. 2003.
Exercise increases
hippocampal neurogenesis to high levels but does not improve spatial learning
in mice bred
for increased voluntary wheel running. Behavioral Neuroscience 117:1006-1016.
[PDF
file]
111.
Johnson, R. A., J. S. Rhodes, S. L. Jeffrey, T. Garland, Jr., and G. S. Mitchell.
2003. Hippocampal
brain-derived
neurotrophic factor but not neurotrophin-3 increases more in mice selected for
increased voluntary
wheel running. Neuroscience 121:1-7. [PDF
file]
113.
Hochstetler, K. J., T. Garland, Jr., J. G. Swallow, P. A. Carter, and A.Bult-Ito. 2004.
Number of arginine-
vasopressin
neurons in the suprachiasmatic nuclei is not related to level or circadian characteristics
of
wheel-running
activity in house mice. Behavior Genetics 34:131-136.
[PDF
file]
114.
Gammie, S. C., N. S. Hasen, J. S. Rhodes, I. Girard, and T. Garland, Jr. 2003.
Predatory aggression, but not
maternal or
intermale aggression, is associated with high voluntary wheel-running behavior
in mice.
Hormones
and Behavior 44:209-221. [PDF
file]
116.
Rhodes, J. S., T. Garland, Jr., and S. C. Gammie. 2003. Patterns of brain activity
associated with
variation in
voluntary wheel-running behavior. Behavioral Neuroscience 117:1243-1256.
[PDF
file]
117.
Koteja, P., J. G. Swallow, P. A. Carter, and T. Garland, Jr. 2003. Different
effects of intensity and
duration of
locomotor activity on circadian period. Journal of Biological Rhythms
18:491-501.
[Abstract]
[PDF file]
118.
Koteja, P., P. A. Carter, J. G. Swallow, and T. Garland, Jr. 2003. Food wasting
in house mice:
variation among
individuals, families, and genetic lines. Physiology & Behavior 80:375-383.
[PDF
file]
121.
Belter, J. G., H. V. Carey, and T. Garland, Jr. 2004. Effects of voluntary exercise
and genetic
selection for
high activity levels on HSP70 expression in house mice.
Journal
of Applied Physiology 96:1270-1276. [PDF
file]
124.
Bronikowski, A. M., J. S. Rhodes, T. Garland, Jr., T. A. Prolla, T. Awad,
and S. C. Gammie. 2004.
The evolution of gene
expression in the hippocampus in response to selective breeding for increased
locomotor activity. Evolution
58:2079-2086. [PDF
file]
127.
Li, G., J. S. Rhodes, I. Girard, S. C. Gammie, and T. Garland, Jr. 2004.
Opioid-mediated pain
sensitivity in mice bred
for high voluntary wheel running. Physiology & Behavior 83:515-524.
[PDF
file]
129.
Morgan, T. J., M. A. Evans, T. Garland, Jr., J. G. Swallow, and P. A.
Carter. 2005.
Molecular and quantitative
genetic divergence among populations of house mice with known
evolutionary histories.
Heredity 94:518-525.
[PDF
file]
130. Swallow, J. G., and T. Garland,
Jr. 2005. Selection experiments as a tool in evolutionary and
comparative physiology:
insights into complex traits - An introduction to the symposium.
Integrative and Comparative
Biology 45:387-390.
[PDF file]
131. Swallow, J. G., J. S. Rhodes, and T. Garland, Jr. 2005. Phenotypic
and evolutionary plasticity of
organ masses in response
to voluntary exercise in house mice. Integrative and Comparative Biology
45:426-437.
[PDF file]
132. Rhodes, J. S., S. C. Gammie, and T. Garland, Jr. 2005. Neurobiology
of mice selected for high
voluntary
wheel-running activity. Integrative and Comparative Biology 45:438-455.
[PDF file]
133.
Rezende, E. L., M. A. Chappell, F. R. Gomes, J. L. Malisch, and T. Garland,
Jr. 2005. Maximal
metabolic rates during
voluntary exercise, forced exercise, and cold exposure in house mice selectively
bred for high wheel-running.
Journal of Experimental Biology 208:2447-2458. [PDF
file]
135.
Syme, D. A., K. Evashuk, B. Grintuch, E. L. Rezende, and T. Garland, Jr. 2005.
Contractile abilities
of
normal and “mini” triceps surae muscles from mice (Mus domesticus)
selectively bred for high
voluntary wheel running. Journal
of Applied Physiology 99:1308-1316. [PDF
file]
136.
Garland, T., Jr., and P. A. Freeman. 2005. Selective breeding for high endurance
running increases
hindlimb symmetry. Evolution
59:1851-1854. [PDF
file]
137.
Rezende, E. L., S. A. Kelly, F. R. Gomes, M. A. Chappell, and T. Garland,
Jr. 2006.
Effects of size, sex,
and voluntary running speeds on costs of locomotion in lines of laboratory mice
selectively bred for high
wheel-running activity. Physiological and Biochemical Zoology 79:83-99.
[PDF
file]
139.
Rezende, E. L., T. Garland, Jr., M. A. Chappell, J. L. Malisch, and F.
R. Gomes. 2006.
Maximum aerobic performance
in lines of Mus selected for high wheel-running activity: effects of
selection,
oxygen availability, and the
mini-muscle phenotype. Journal of Experimental Biology 209:115-127.
[PDF file]
141.
Kelly, S. A., P. P. Czech, J. T. Wight, K. M. Blank, and T. Garland, Jr.
2006.
Experimental evolution
and phenotypic plasticity of hindlimb bones in high-activity house mice.
Journal of Morphology
267:360-374. [PDF file]
143.
Guderley, H., P. Houle-Leroy, G. M. Diffee, D. M. Camp, and T. Garland, Jr.
2006. Morphometry, ultrastructure,
myosin isoforms, and metabolic
capacities of the "mighty mini muscles" favoured by selection for
high activity
in house mice. Comparative
Biochemistry and Physiology Part B: Biochemistry and Molecular Biol. 144:271-282.
[PDF file]
145.
Rezende, E. L., F. R. Gomes, J. L. Malisch, M. A. Chappell, and T. Garland, Jr. 2006. Maximal oxygen
consumption in relation to subordinate traits in lines of house mice selectively bred for high voluntary
wheel running. Journal of Applied Physiology 101:477-485. [PDF file]
146.
Zhang, Y., T.-S. Lee, E. M. Kolb, K. Sun, X. Lu, F. M. Sladek, G. S. Kassab, T. Garland, Jr., and J. Y.-J. Shyy.
2006. AMP-activated protein kinase is involved in endothelial nitric-oxide synthase activation in response
to shear stress. Arteriosclerosis, Thrombosis, and Vascular Biology 26:1281-1287. [PDF file]
Faculty of 1000 Selection!
147. Bronikowski, A. M., T. Morgan, T. Garland, Jr., and P.A. Carter. 2006. The evolution
of aging and age-related physical decline in mice selectively bred for high voluntary exercise.
Evolution 60:1494-1508. [PDF file]
148. Garland,
T., Jr., and S. A. Kelly. 2006. Phenotypic plasticity and experimental evolution.
Journal of Experimental Biology 209:2344-2361. [PDF file]
150. Krugner-Higby, L., I. Girard, J. Welter, A. Gendron, J. S. Rhodes, and T. Garland Jr. 2006.
Clostridial enteropathy in lactating outbred swiss-derived (ICR) mice.
Journal of the American Association for Laboratory Animal Science 45:80-87. [PDF file]
151. Vaanholt, L. M., T. Garland Jr., S. Daan, and G. H. Visser. 2006. Wheel-running activity and energy metabolism
in relation to ambient temperature in mice selected for high wheel-running activity.
Journal of Comparative Physiology B 177:109-118. [PDF file]
152. Malisch, J. L., W. Saltzman, F. R. Gomes, E. L. Rezende, D. R. Jeske, and T. Garland, Jr. 2007.
Baseline and stress-induced plasma corticosterone concentrations of mice selectively bred for high
voluntary wheel running. Physiological and Biochemical Zoology 80:146-156. [PDF file]
154. Belke, T. W., and T. Garland, Jr. 2007. A brief opportunity to run does not function as a reinforcer for mice selected
for high daily wheel-running
rates. Journal of the Experimental Analysis of Behavior 88:199-213. [PDF file]
155. Vaanholt, L. M., P. Meerlo, T. Garland, Jr., G. H. Visser, and G. van Dijk. 2007. Plasma adiponectin is increased
in mice selectively bred for high wheel-running activity, but not by wheel running per sé.
Hormone and Metabolic Research 39:377-383. [PDF file]
156. Vaanholt, L. M., B. De Jong, T. Garland, Jr., S. Daan, and G. H. Visser. 2007. Behavioural and physiological
responses to increased foraging effort in male mice. Journal of Experimental Biology 210:2013-2024. [PDF file]
160. Girard, I., E. L. Rezende,
and T. Garland, Jr. 2007. Leptin levels and body composition of mice selectively
bred for high voluntary activity. Physiological and Biochemical Zoology 80:568-579. [PDF file]
162. Middleton, K. M., C. E. Shubin, D. C. Moore, P. A. Carter, T. Garland, Jr., and S. M. Swartz. 2008.
The relative importance of genetics and phenotypic plasticity in dictating bone morphology and mechanics
in aged mice: evidence from an artificial selection experiment. Zoology 111:135-147. [PDF
file]
163. Vaanholt,
L. M., J. R. Speakman, T. Garland Jr., G. E. Lobley, and G. H. Visser. 2008.
Protein synthesis and
antioxidant capacity in
aging mice: effects of long-term voluntary exercise.
Physiological and Biochemical Zoology 81:148-157. [PDF file]
164. Guderley, H., D. R. Joanisse, S. Mokas, G. M. Bilodeau, and T. Garland,
Jr. 2008. Altered fiber types
in gastrocnemius muscle
of high wheel-running selected mice with mini muscle phenotypes.
Comparative Biochemistry
and Physiology, Part B 149:490-500. [PDF file]
165. Kane, S. L., T. Garland, Jr., and P. A. Carter. 2008. Basal metabolic rate of aged mice is affected by random
genetic drift but not by selective breeding for high early-age locomotor activity or chronic wheel access.
Physiological and Biochemical
Zoology 81:288-300. [PDF_file]
166. Hannon, R. M., S. A. Kelly, K. M. Middleton, E. M. Kolb, D. Pomp,
and T. Garland, Jr. 2008.
Phenotypic effects of the “mini-muscle” allele
in a large HR x C57BL/6J mouse backcross.
Journal of Heredity 99:349-354.
[PDF file]
167. Malisch, J. L., C. W. Breuner, F. R Gomes, M. A. Chappell, and T. Garland, Jr. 2008.
Circadian pattern of total and free corticosterone concentrations, corticosteroid-binding globulin,
and physical activity in mice selectively bred for high voluntary wheel-running behavior.
General and Comparative Endocrinology 156:210-217. [PDF file]
169. Hartmann, J., T. Garland, Jr., R. M. Hannon, S. A. Kelly, G. Muñoz, and D. Pomp. 2008. Fine mapping
of "Mini-Muscle", a recessive mutation causing reduced hind-limb muscle mass in mice.
Journal of Heredity 99:679-687.
[PDF file]
171. Middleton, K. M., S. A. Kelly, and T. Garland, Jr. 2008. Selective breeding as a tool to probe
skeletal response to high voluntary locomotor activity in mice.
Integrative and Comparative Biology 48:394-410. [PDF file]
172. Vaanholt, L. M., I. Jonas, M. Doornbos, K. A. Schubert, C. Nyakas, T. Garland, Jr., G. H. Visser,
and Gertjan van Dijk. 2008. Responses in energy balance to high-fat feeding in mice selectively
bred for high wheel-running activity. International
Journal of Obesity 32:1566-1575. [PDF file]
173. Yan, R. H., J. L. Malisch, R. M. Hannon, P. L. Hurd, and T. Garland, Jr. 2008. Selective
breeding for a behavioral trait changes digit ratio. PLoS
ONE 3(9):e3216. doi:10.1371/journal.pone.0003216. [PDF file]
175. Keeney, B. K., D. A. Raichlen, T. H. Meek, R. S. Wijeratne, K. M. Middleton, G. L. Gerdeman,
and T. Garland, Jr. 2008. Differential response to a selective cannabinoid
receptor antagonist (SR141716: rimonabant) in female mice from lines selectively bred for high
voluntary wheel-running behavior. Behavioural Pharmacology 19:812-820. [PDF
file]
176. Malisch, J. L., S. A. Kelly, A. Bhanvadia, K. M. Blank, R. L. Marsik, E. G. Platzer, and T. Garland, Jr.
2009. Lines of mice with chronically elevated baseline corticosterone are more
susceptible to a parasitic nematode
infection. Zoology 112:316-324. [PDF
file]
177. Gomes, F. R., E. L. Rezende, J. L. Malisch, S. K. Lee, D. A. Rivas, S. A. Kelly, C. Lytle,
B. B. Yaspelkis III, and T. Garland, Jr. 2009. Glycogen storage and muscle glucose transporters
(GLUT-4) of mice selectively bred for high voluntary wheel running.
Journal of Experimental Biology 212:238-248.
[PDF file]
178. Malisch, J. L., C. W. Breuner, E. M. Kolb, H. Wada, R. M. Hannon, M. A. Chappell, K. M. Middleton,
and T. Garland, Jr. 2009. Behavioral despair and home-cage activity in mice with chronically elevated
baseline corticosterone concentrations. Behavior Genetics 39:192-201. [PDF file]
179. Bilodeau, G. M., H. Guderley, D. R. Joanisse, and T. Garland, Jr. 2009. Reduction of type IIb myosin and
IIB fibers in tibialis anterior muscle of mini-muscle mice from high-activity lines.
Journal of Experimental Zoology Part A: Ecological Genetics and Physiology 311A:189-198. [PDF file]
180. McGillivray, D. G., T. Garland, Jr., E. M. Dlugosz, M. A. Chappell, and D. A. Syme. 2009.
Changes in efficiency and myosin expression in the small-muscle phenotype of mice selectively bred
for high voluntary running activity. Journal of Experimental Biology 212:977-985. [PDF file]
181. Young, N. M., B. HallgrÃmsson, and T. Garland, Jr. 2009. Epigenetic effects on integration of limb lengths
in a mouse model: selective breeding for high voluntary locomotor activity. Evolutionary Biology 36:88-99.
[PDF file]
183. Nehrenberg, D. L., K. Hua, D. Estrada-Smith, T. Garland, Jr., and D. Pomp. 2009. Voluntary exercise and its
effects on body composition depend on genetic selection history. Obesity 17:1402-1409. [PDF file]
184. Wong, L. E., T. Garland, Jr., S. Rowan, and R. T. Hepple. 2009. Anatomic capillarization is elevated in the
medial gastrocnemius muscle of mighty mini mice. Journal of Applied Physiology 106:1660-1667. [PDF file]
185. Eisenmann, J. C., E. E. Wickel, S.
A. Kelly, K. M. Middleton,
and T. Garland, Jr. 2009. Day-to-day variability
in voluntary wheel running among genetically
differentiated lines of mice that vary in activity level.
European Journal of Applied Physiology 106:613-619.
[PDF file]
188. Dlugosz, E. M., M. A. Chappell, D. G. McGillivray,
D. A. Syme, and T. Garland, Jr. 2009. Locomotor
trade-offs in mice selectively bred
for high voluntary wheel running.
Journal of Experimental Biology 212:2612-2618.
[PDF file]
189. Meek, T. H., B. P. Lonquich, R. M. Hannon, and T. Garland, Jr. 2009. Endurance
capacity of mice selectively
bred for high voluntary wheel running. Journal
of Experimental Biology 212: 2908-2917. [PDF
file]
191. Swallow, J. G., J. P. Hayes, P. Koteja, and T. Garland, Jr. 2009. Selection experiments and experimental
evolution of performance and physiology. Pages 301-351 in Experimental Evolution: Concepts,
Methods, and Applications of Selection Experiments, T. Garland, Jr., and M. R. Rose, eds.
University of California Press, Berkeley, California. [PDF
file]
192. Rezende, E. L., F. R. Gomes, M. A. Chappell, and T. Garland, Jr. 2009. Running behaviour and its energy
cost in mice selectively bred for high voluntary locomotor activity.
Physiological and Biochemical Zoology 82:662-679. [PDF file]
193. Nehrenberg, D. L., S. Wang, R. M. Hannon, T. Garland, Jr., and D. Pomp. 2010. QTL underlying voluntary
exercise in mice: interactions with the “mini muscle” locus and sex. Journal
of Heredity 101:42-53.
[PDF file]
195. Feder, M. E., T. Garland, Jr., J. H. Marden, and A. J. Zera. 2010. Locomotion in response to shifting climate
zones: not so fast. Annual Review of Physiology 72:167-190.
[PDF file] (includes
review of rodent selection experiments)
196. Vaanholt, L. M., S. Daan,T. Garland, Jr., and G. H. Visser. 2010. Exercising for life? Energy metabolism,
body composition, and longevity in mice exercising at different intensities.
Physiological and Biochemical Zoology 83:239-251. [PDF file]
198. Kolb, E. M., S. A. Kelly, K. M. Middleton, L. S. Sermsakdi, M. A. Chappell, and T. Garland, Jr. 2010. Erythropoietin
elevates VO2,max but not voluntary
wheel running in mice. Journal of Experimental Biology 213:510-519.
[PDF file]
200. Middleton, K. M., T. Garland, Jr., B. D. Goldstein, P. R. Guduru, S. A. Kelly, and S. M. Swartz. 2010.
Variation in within-bone stiffness
measured by nanoindentation in mice bred for high levels of
voluntary wheel running. Journal of Anatomy 216:121-131. [PDF file]
201. Kelly, S. A., D. L. Nehrenberg, K. Hua, R. R. Gordon, T. Garland, Jr., and D. Pomp. 2010. Parent-of-origin
effects on voluntary exercise levels
and body composition in mice. Physiological Genomics 40:111-120.
[PDF
file]
202. Meek, T. H., J. C. Eisenmann, and T. Garland, Jr. 2010. Western diet increases
wheel running in mice
selectively bred for high voluntary
wheel running. International
Journal of Obesity 34:960-969. [PDF
file]
203. Jonas, I., M. Doornbos, L. Vaanholt, T. Garland, Jr, A.
J. W. Scheurink, C. Nyakas, and G. van Dijk. 2010.
Effects of selective breeding for
increased wheel running behavior on circadian timing of substrate
oxidation and ingestive behavior. Physiology & Behavior 99:549-554.
[PDF file]
204. Wallace, I. J., K. M. Middleton, S. Lublinsky, S. A. Kelly, S. Judex, T.
Garland, Jr., and B. Demes. 2010.
Functional significance of genetic
variation underlying limb bone diaphyseal structure.
American Journal of Physical Anthropology 143:21-30. [PDF file]
205. Mathes, W. F., D. L. Nehrenberg, R. Gordon, K. Hua,
T. Garland, Jr., and D. Pomp. 2010.
Dopaminergic dysregulation in mice
selectively bred for excessive exercise or obesity.
Behavioural Brain Research 210:155-163.
[PDF file]
206. Jonas, I., K. A. Schubert, A. C. Reijne, J. Scholte, T.
Garland, Jr., M. P. Gerkema, A. J. W. Scheurink, C. Nyakas,
and G. van Dijk. 2010. Behavioral
traits are affected by selective breeding for increased wheel-running
behavior in mice. Behavior Genetics 40:542-550. [PDF file]
207. Kelly, S. A., D. L. Nehrenberg, J. L. Peirce, K.
Hua, B. M. Steffy, T. Wiltshire, F. Pardo Manuel de Villena,
T. Garland, Jr., and D. Pomp. 2010.
Genetic architecture of voluntary exercise in an advanced intercross line of
mice.
Physiological Genomics 42:190-200. [PDF file]
211. Garland, T., Jr., S. A. Kelly, J. L. Malisch, E. M. Kolb,
R. M. Hannon, B. K. Keeney, S. L. Van Cleave,
and K. M. Middleton. 2011. How to
run far: Multiple solutions and sex-specific responses to selective
breeding for high voluntary activity
levels. Proceedings of the Royal Society B 278:574-581. [PDF
file]
UCR
Press Release
To
see a video of Dr. Garland discussing the research, click here.
214. Hannon, R. M., T. H. Meek, W. Acosta, R. C. Maciel, H. Schutz, and T. Garland,
Jr. 2011. Sex-specific heterosis
in line crosses of mice selectively
bred for high locomotor activity. Behavior Genetics 41:615-624. [PDF
file]
215. Kelly, S. A., D. L. Nehrenberg, K. Hua, T. Garland,
Jr., and D. Pomp. 2011. Exercise, weight loss, and
changes in body composition in mice:
phenotypic relationships and genetic architecture.
Physiological Genomics 43:199-212.
[PDF file]
220. Farber, C. R., S. A. Kelly, E. Baruch, D. Yu, K. Hua, D. L. Nehrenberg,
F. Pardo-Manuel de Villena, R. J. Buus,
T. Garland, Jr., and D. Pomp. 2011.
Identification of quantitative trait loci influencing skeletal architecture in
mice:
emergence of Cdh11 as a primary
candidate gene regulating femoral morphology.
Journal of Bone and Mineral Research 26:2174-2183.
[PDF file]
222. Audet, G. N., T. H. Meek, T. Garland, Jr., and I. M. Olfert. 2011. Expression
of angiogenic regulators and skeletal
muscle capillarity in selectively
bred high aerobic capacity mice. Experimental Physiology 96.11:1138-1150.
[PDF
file]
Commentary Viewpoint by Birot, O. 2011. Genetic background, endurance performance and muscle capillarization: lessons from the “mini mice.”
Experimental Physiology 96:1116–1117. [PDF file]
225. Wallace, I. J., S. M. Tommasini, S. Judex, T. Garland,
Jr., and B. Demes. 2012. Genetic variations and physical
activity as
determinants of limb bone morphology: an experimental approach using a mouse
model.
American Journal of Physical Anthropology 148:24-35. [PDF
file]
226. Downs, C. J., H. Schutz, T. H. Meek, E. M. Dlugosz, W. Acosta, K. S. de Wolski, J. L. Malisch, J. P. Hayes,
and T. Garland, Jr. 2012. Within life-time trade-offs but evolutionary freedom for hormonal and immunological
traits: evidence from mice bred for high voluntary exercise. Journal of Experimental Biology 215:1651-1661. [PDF
file]
227. Meek, T. H., E. M. Dlugosz, K. T. Vu, and T. Garland, Jr. 2012. Effects
of leptin treatment and Western diet
on wheel running in selectively bred
high runner mice. Physiology & Behavior 106:252-258. [PDF
file]
228. Keeney, B. K., T. H. Meek, K. M. Middleton, L. F. Holness, and T. Garland,
Jr. 2012. Sex differences in
cannabinoid receptor-1 (CB1) pharmacology
in mice selectively bred for high voluntary wheel-running behavior.
Pharmacology, Biochemistry and
Behavior 101:528-537. [PDF
file]
229. Kelly, S. A., D. L. Nehrenberg, K. Hua, T. Garland, Jr., and D. Pomp. 2012.
Functional genomic architecture of
predisposition to voluntary exercise
in mice: expression QTL in the brain. Genetics 191:643-654. [PDF
file]
232. Careau, V. C., O. R. P. Bininda-Emonds, G. Ordonez, and T. Garland, Jr. 2012. Are voluntary wheel running
and open-field behavior correlated in mice? Different answers from comparative and artificial selection approaches.
Behavior Genetics 42:830-844.
[PDF
file]
233. Templeman, N. M., H. Schutz, T. Garland, Jr., and G. B. McClelland. 2012.
Do mice bred selectively for high
locomotor activity have a greater reliance on lipids to power submaximal aerobic exercise?
American Journal of Physiology
Regulatory Integrative and Comparative Physiology 303:R101-R111. [PDF
file]
236. Kolb, E. M., E. L. Rezende, L. Holness, A. Radtke, S. K. Lee, A. Obenaus,
and T. Garland, Jr. 2013.
Mice selectively bred for high voluntary
wheel running have larger midbrains: support for the mosaic
model of brain evolution. Journal
of Experimental Biology 216:515-523. [PDF
file]
[UCR
Today]
[Science
Daily news story] [Deccan
Herald] [NBC
Los Angeles] [Animal
Abstracts]
[Medical
News Today]
[Many
Years Young] [Indian
Express] [moneycontrol.com]
[Business
Standard]
237. Waters, R. P., R. B. Pringle, G. L. Forster, K. J. Renner, J. L. Malisch,
T. Garland, Jr., and J. G. Swallow. 2013.
Selection for increased voluntary
wheel-running affects behavior and brain monoamines in mice.
Brain Research 1508:9-22.
[PDF
file]
238. Burniston, J. G., T. H. Meek, S. N. Pandey, G. Broitman-Maduro, M. F. Maduro,
A. M. Bronikowski,
T. Garland, Jr., and Y.-W. Chen. 2013.
Gene expression profiling of gastrocnemius of "minimuscle" mice.
Physiological Genomics 45:228-236.
[PDF
file]
239. Kolb, E. M., S. A. Kelly, and T. Garland, Jr. 2013. Mice from lines selectively bred for high voluntary
wheel running exhibit lower blood pressure during withdrawal from wheel access.
Physiology & Behavior 112-113:49-55. [PDF file]
240. Careau, V., M. E. Wolak, P. A. Carter, and T. Garland, Jr. 2013. Limits to behavioral evolution:
the quantitative genetics of a complex trait under directional selection. Evolution 67:3102-3119. [PDF file]
242. Dlugosz, E. M., H. Schutz, T. H. Meek, W. Acosta, C. J. Downs, E. G. Platzer, M. A. Chappell, and T. Garland, Jr.
2013. Immune response to a Trichinella spiralis infection in house mice from lines selectively bred for high
voluntary wheel running. Journal of Experimental Biology 216:4212-4221. [PDF file]
244. Kelly, S. A., T. A. Bell, S. R. Selitsky, R. J. Buus, K. Hua, G. M. Weinstock, T. Garland, Jr.,
F. Pardo-Manuel de Villena, and D. Pomp. 2014. A novel intronic SNP in the Myosin heavy polypeptide
4 gene is responsible for the Mini-Muscle phenotype characterized by major reduction in hindlimb muscle
mass in mice. Genetics 195:1385-1395. [PDF file]
245. Guidotti, S., I. Jonas, K. M. Schubert, T. Garland, Jr., H. A. J. Meijer, A. J. W. Scheurink, and G van Dijk. 2014.
High-saturated fat-sucrose feeding affects lactation energetics in control mice and mice selectively bred for high
wheel-running behavior. American Journal of Physiology-Regulatory, Comparative and Integrative Physiology.
305:R1433-440. [PDF File]
247. Meek, T. H., J. C. Eisenmann, B. K. Keeney, R. M. Hannon, E. M. Dlugosz, and T. Garland, Jr. 2014.
Effects of early- life exposure to Western diet and wheel access on Metabolic Syndrome profiles in mice
bred for high voluntary exercise. Genes, Brain and Behavior 13:322-332. [PDF file]
248. Kelly, S. A., E. L. Rezende, M. A. Chappell, F. R. Gomes, E. M. Kolb, J. L. Malisch, J. S. Rhodes, G. S. Mitchell,
and T. Garland, Jr. 2014. Exercise training effects on hypoxic and hypercapnic ventilatory responses in mice selected
for increased voluntary wheel running. Experimental Physiology 99:403-413. [PDF File]
251. Radojcic, T., and T. Garland, Jr. 2014. Born to run: Experimental evolution of high voluntary exercise in mice.
Science Scope 37:51-60. [PDF File] This is about the active-learning, middle-school lesson plan.
253. Kelly, S. A., D. L. Nehrenberg, K. Hua, T. Garland, Jr., and D. Pomp. 2014. Quantitative genomics of voluntary exercise
in mice: transcriptional analysis and mapping of expression QTL in muscle. Physiological Genomics 46:593-601. [PDF File]
256. Schutz, H., H. A. Jamniczky, B. Hallgrímsson, and T. Garland, Jr. 2014. Shape-shift: semicircular canal morphology
responds
to selective breeding for increased locomotor activity. Evolution 68:3184-3198. [PDF file]
257. Talmadge, R. J., W. Acosta, and T. Garland, Jr. 2014. Myosin heavy chain isoform expression in adult and juvenile
mini-muscle mice bred for high-voluntary wheel running. Mechanisms of Development 134:16-30. [PDF file]
259. Didion, J. P., A. P. Morgan, A. M.-F. Clayshulte, R. C. Mcmullan, L. Yadgary, P. M. Petkov, T. A. Bell, D. M. Gatti, J. J. Crowley,
K. Hua, D. L. Aylor , L. Bai, M. Calaway, E. J. Chesler, J. E. French, T. R. Geiger, T. J. Gooch, T. Garland, Jr., A. H. Harrill,
K. Hunter, L. McMillan, M. Holt, D. R. Miller, D. A. O'Brien, K. Paigen, W. Pan, L. B. Rowe, G. D. Shaw, P. Simecek,
P. F. Sullivan, K. L. Svenson, G. M. Weinstock, D. W. Threadgill, D. Pomp, G. A. Churchill. and F. Pardo-Manuel de Villena.
2015. A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse Chromosome 2.
PLoS Genetics. 11(2): e1004850. doi:10.1371/journal.pgen.1004850 [PDF file]
261. Copes, L. E., H. Schutz, E. M. Dlugosz, W. Acosta, M. A. Chappell, and T. Garland, Jr. 2015. Effects of voluntary exercise
on spontaneous physical activity and food consumption in mice: Results from an artificial selection experiment.
Physiology & Behavior 149:86-94. [PDF file]
262. Acosta, W., T. H. Meek, H. Schutz, E. M. Dlugosz, K. T. Vu, and T. Garland, Jr. 2015. Effects of early-onset voluntary exercise
on adult physical activity and associated phenotypes in mice. Physiology & Behavior 149:279-286. [PDF file]
UCR press release
263. Storz, J. F., J. T. Bridgham, S. A. Kelly, and T. Garland, Jr. 2015. Genetic approaches in comparative and evolutionary physiology.
American Journal of Physiology (Regulatory, Integrative and Comparative Physiology) 309:R197-R214. [PDF file]
266. Careau, V., M. E. Wolak, P. A. Carter, and T. Garland, Jr. 2015. Evolution of the additive genetic variance-covariance matrix under
continuous directional selection on a complex behavioral phenotype. Proceedings of the Royal Society B 282:20151119.
http://dx.doi.org/10.1098/rspb.2015.1119. [PDF file]
267. Careau, V., M. E. Wolak, P. A. Carter, and T. Garland, Jr. 2015. Evolution of the additive genetic variance-covariance matrix under
continuous directional selection on a complex behavioral phenotype. Proceedings of the Royal Society B 282:20151119.
http://dx.doi.org/10.1098/rspb.2015.1119. [PDF file]
270. Guidotti, S., N. Meyer, E. Przybyt, A. J. W. Scheurink, M. C. Harmsen, T. Garland, Jr., and G. van Dijk. 2016.
Diet-induced obesity resistance of adult female mice selectively bred for increased wheel-running behavior is reversed
by single perinatal exposure to a high-energy diet. Physiology & Behavior 157:246-257. [PDF file]
271. Didion, J. P., A. P Morgan, L. Yadgary, T. A. Bell, R.l C. McMullan, L. Ortiz de Solorzano, J. Britton-Davidian, C. J. Bult,
K. J. Campbell, R. Castiglia, Y.-H. Ching, A. J. Chunco, J. J. Crowley, E. J. Chesler, J. E. French, S. I. Gabriel, D. M. Gatti,
T. Garland Jr., E. B. Giagia-Athanasopoulou, M. D. Giménez, S. A. Grize, İ. Gündüz, A. Holmes, H. C. Hauffe, J. S. Herman,
J. M. Holt, K. Hua, W. J. Jolley, A. K. Lindholm, M. J. López-Fuster, G. Mitsainas, M. Mathias, L. McMillan, M. Graça Ramalhinho,
B. Rehermann, S. P. Rosshart, J. B. Searle, M.-S. Shiao, E. Solano, K. L. Svenson, P. Thomas-Laemont, D. W. Threadgill,
J. V. Queija, G. M. Weinstock, D. Pomp, G. A. Churchill, and F. Pardo-Manuel de Villena. 2016.
R2d2 drives selfish sweeps in the house mouse. Molecular Biology and Evolution 33:1381-1395. [PDF file]
272. Claghorn, G. C., I. A. T. Fonseca, Z. Thompson, C. Barber, and T. Garland, Jr. 2016. Serotonin-mediated central fatigue underlies
increased endurance capacity in mice from lines selectively bred for high voluntary wheel running. Physiology & Behavior 161:145-154. [PDF file]
Blog by Chris Perry: "It’s what’s inside that counts. But what’s inside? The role of serotonin and central fatigue."
https://medsportsnutrition.com/2016/05/31/its-whats-inside-that-counts-but-whats-inside-the-role-of-serotonin-and-central-fatigue/
273.
Wallace, I. J., and T. Garland, Jr. 2016. Mobility as an emergent property of biological organization:
insights from experimental evolution. Evolutionary Anthropology 25:98-104. [PDF file]
274. Hiramatsu, L., and T. Garland, Jr. 2016. Nature or nurture? Heritability in the classroom.
Physiological and Biochemical Zoology 89:457-461. [PDF file]
275. Malisch, J. L., K. deWolski*, T. H. Meek, W. Acosta, K. M. Middleton, O. L. Crino, and T. Garland, Jr. 2016.
Acute restraint stress alters wheel-running behavior immediately following stress and up to 20 hours later in house mice.
Physiological and Biochemical Zoology 89:546-552. [PDF file]
276.
Garland, T., Jr., M. Zhao, and W. Saltzman. 2016. Hormones and the evolution of complex traits: insights from
artificial selection on behavior. Integrative and Comparative Biology 56:207-224. [PDF file] [Supplemental Excel file]
277. Caetano-Anollés, K., J. S. Rhodes, T. Garland, Jr., S. D. Perez, A. G. Hernandez, B. R. Southey, S. L. Rodriguez-Zas. 2016. Cerebellum
transcriptome
of mice bred for high voluntary activity offers insights into locomotor control and reward-dependent behaviors.
PloS ONE. 11(11): e0167095. doi:10.1371/journal.pone.0167095. [PDF file]
278. Claghorn, G. C., Z. Thompson, K. Wi*, L. Van*, and T. Garland, Jr. 2017. Caffeine stimulates voluntary wheel running in mice
without increasing aerobic capacity. Physiology & Behavior 170:133-140. [PDF file]
279. Saul, M., P. Majdak, S. D. Perez, T. Garland, Jr., and J. S. Rhodes. 2017. High motivation for exercise is associated with altered chromatin
regulators of monoamine receptor gene expression in the striatum of selectively bred mice. Genes, Brain and Behavior 16: 328-341. [PDF file]
280. Marck, A., G. Berthelot, V. Foulonneau, A. Marc, J. Antero-Jacquemin, P. Noirez, A. M. Bronikowski, T. J. Morgan, T. Garland, Jr.,
P. A. Carter, P. Hersen, J.-M. Di Meglio, and J.-F. Toussaint. 2017. Age-related changes in locomotor performance reveal a similar pattern
for Caenorhabditis elegans, Mus domesticus, Canis familiaris, Equus caballus, and Homo sapiens. Journals of Gerontology: Biological Sciences
72:455-463. [PDF file]
281. Acosta, W., T. H. Meek, H. Schutz, E. M. Dlugosz, and T. Garland, Jr. 2017. Preference for Western diet coadapts in High Runner mice and affects
voluntary exercise and spontaneous physical activity in a genotype-dependent manner. Behavioural Processes 135:56-65. [PDF file]
282. Thompson, Z., D. Argueta, T. Garland, Jr., and N. DiPatrizio. 2017. Circulating levels of endocannabinoids respond acutely to voluntary exercise,
are altered in mice selectively bred for high voluntary wheel running, and differ between the sexes. Physiology & Behavior 170:141-150. [PDF file]
283. Garland, T., Jr., M. D. Cadney, and R. A. Waterland. 2017. Early-life effects on adult physical activity:
concepts, relevance, and experimental approaches. Physiological and Biochemical Zoology 90:1-14. [PDF file]
284. Kelly, S. A., F. R. Gomes, E. M. Kolb, J. L. Malisch, and T. Garland, Jr. 2017. Effects of activity, genetic selection and their interaction
on muscle metabolic capacities and organ masses in mice. Journal of Experimental Biology 220:1038-1047. [PDF file]
286. Hiramatsu, L., J. C. Kay, Z. Thompson, J. M. Singleton, G. C. Claghorn, R. L. Albuquerque, B. Ho*, B. Ho*, G. Sanchez*, and T. Garland, Jr. 2017.
Maternal exposure to Western diet affects adult body composition and voluntary wheel running in a genotype-specific manner in mice.
Physiology & Behavior 179:235-245. [PDF file]
287. Claghorn, G. C., Z. Thompson, J. C. Kay, G. Ordonez, T. G. Hampton, and T. Garland, Jr. 2017. Selective breeding and short-term access
to a running wheel alter stride characteristics in house mice. Physiological and Biochemical Zoology 90:533-545. [PDF file]
291. Xu, S., and T. Garland, Jr. 2017. A mixed model approach to genome-wide association studies for selection signatures,
with application to mice bred for voluntary exercise behavior. Genetics 207:785-799. [PDF file]
293. Thompson, Z., E. M. Kolb, and T. Garland, Jr. 2017. High-runner mice have reduced incentive salience for a sweet-taste reward
when housed with wheel access. Behavioural Processes 146:46-53. [PDF file]
295. Peacock, S. J., B. R. Coats, J. K. Kirkland, C. A. Tanner, T. Garland, Jr., K. M. Middleton. 2018. Predicting the bending properties
of long bones: insights from an experimental mouse model. American Journal of Physical Anthropology 165:457-470. [PDF file]
296. Lightfoot, J. T., E. J. C. De Geus, F. W. Booth, M. S. Bray, M. den Hoed, J. Kaprio, S. A. Kelly, D. Pomp, M. C. Saul, M. A. Thomis, T. Garland, Jr.,
and C. Bouchard. 2018. Biological / genetic regulation of physical activity level: consensus from GenBioPAC.
Medicine and Science in Sports and Exercise 50:863-873. [PDF file]
299. Copes, L. E., H. Schutz, E. M. Dlugsoz, and T. Garland, Jr. 2018. Locomotor activity, hormones, and systemic robusticity:
an investigation of cranial vault thickness in mouse lines bred for high endurance running.
American Journal of Physical Anthropology 166:442-458. [PDF file]
300. Biro, P. A., T. Garland, Jr., C. Beckmann, B. Ujvari, F. Thomas, and J. R. Post. 2018. Metabolic scope as a proximate constraint on
individual behavioral variation: effects on 'personality', plasticity, and predictability. American Naturalist 192:142-154. [PDF file]
301. Hiramatsu, L., and T. Garland, Jr. 2018. Mice selectively bred for high voluntary wheel-running behavior conserve more fat
despite increased exercise. Physiology & Behavior 194:1-8. [PDF file]
302. Castro, A. A., and T. Garland, Jr. 2018. Evolution of hindlimb bone dimensions and muscle masses in house mice selectively bred
for high voluntary wheel-running behavior. Journal of Morphology 279:766-779. [PDF file]
303. Schwartz, N. L., B. A. Patel, T. Garland, Jr., and A. M. Horner 2018. Effects of selective breeding for high voluntary wheel-running
behavior on femoral nutrient canal size and abundance in house mice. Journal of Anatomy 233:193-203. [PDF file]
304. Peacock, S. J., T. Garland, Jr., and K. M. Middleton. 2018. Reply to Ruff, Warden, and Karlson.
American Journal of Physical Anthropology 167:190-193. [PDF file]
305. Zhang, P., J. S. Rhodes,T. Garland, Jr., S. Perez, B. Southey, and S. L. Rodriguez-Zas. 2018. Brain region-dependent gene networks
associated with selective breeding for increased voluntary wheel-running behavior. PLoS ONE. 13(8):e0201773. [PDF file]
306. Kay, J. C., J. Ramirez, E. Contreras, and T. Garland, Jr. 2018. Reduced non-bicarbonate skeletal muscle buffering capacity in mice with
the mini-muscle phenotype. Journal of Experimental Biology 221:jeb172478. [PDF file]
307. Singleton, J. S., and T. Garland, Jr. 2019. Influence of corticosterone on growth, home-cage activity, wheel running, and aerobic capacity
in house mice selectively bred for high voluntary wheel-running behavior. Physiology & Behavior 198:27-41. [PDF file]
309. Kay, J. C., G. C. Claghorn, Z. Thompson, T. G. Hampton, and T. Garland, Jr. 2019. Electrocardiograms of mice selectively bred for
high levels of voluntary exercise: Effects of short-term exercise training and the mini-muscle phenotype.
Physiology & Behavior 199:322-332. [PDF file]
310. Dewan, I., T. Garland, Jr., L. Hiramatsu, and V. Careau. 2019. I smell a mouse: indirect genetic effects on voluntary wheel-running
distance, duration and speed. Behavior Genetics 49:49-59. [PDF file]
311. Wone, B., W. C. Kim, H. Schutz, T. H. Meek, and T. Garland, Jr. 2019. Mitochondrial haplotypes are not associated with mice
selectively bred for high voluntary wheel running. Mitochondrion 46:134-139. [PDF file]
312. Lewton, K. L., T. Ritzman, L. E. Copes, T. Garland, Jr., and T. D. Capellini. 2019. Exercise-induced loading increases ilium
cortical area in a selectively-bred mouse model. American Journal of Physical Anthropology 168:543-551. [PDF file]
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Last Updated 12 April 2020 by T.G.
