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Experimental Evolution Publications by Ted Garland

Experimental Evolution Publications by Ted Garland: Artificial Selection for High Voluntary Wheel-Running Behavior in House Mice

Inquiry-Based Middle School Lesson Plan -- "Born to Run: Artificial Selection Lab"
PDF version

Table of Contents for:
Garland, T., Jr., and M. R. Rose, eds. 2009. Experimental evolution: concepts, methods, and applications
    of selection experiments. University of California Press, Berkeley, California.
PDF copies of the individual chapters can be obtained from the individual authors or from me.

Network for Experimental Research on Evolution (NERE)

Intercampus Research Program on Experimental Evolution (UCIRPEE) (previous incarnation of NERE)

Videos on the High Runner Mice:
     Video of Mice Running on Wheel (Girard et al. 2001) 
     Garland Public Lecture on "Born to Run: Evolution of Hyperactivity in Mice" 29 Oct. 2009
     Dr. Garland discussing "How to run far: Multiple solutions and sex-specific responses to selective breeding ..."    PDF file 
     Dr. Garland discussing the High Runner mice in a short video
     YouTube Channel

Stories on the High Runner Mice as Exercise Addicts:
"Fit and Dim?" by Lee Dye for ABCNews.com
ScienCentral.com
Sciencemag.org or view PDF file here
       Holden, C. 2001.‘Behavioral ’Addictions: Do They Exist? Science 294:980-982.
http://www.news.wisc.edu/9208.html

Other Stories on the High Runner Mice:
Focus on "Lifelong voluntary exercise in the mouse prevents age-related alterations in gene expression in the heart"
"Running mice are leaner" by Henry Gee for Nature
"Fitness fanatic or couch potato? Blame your DNA" by Christie Aschwanden for the Los Angeles Times
Sports Illustrated article on "Sports Genes" by David Epstein -- mice are mentioned on last page

Textbook Features on our Research with the High Runner Mice:
Two-page Box on the mouse selection experiment in 2006 Comparative Physiology text by Moyes and Schulte
Two-pages on the mouse selection experiment in 2014 Evolutionary Analysis text by Herron and Freeman (with contributions by Hodin, Miner, Sidor)
Page discussing a selection experiment on mouse maternal aggression by Stephen Gammie that Ted helped with in 2014 Evolutionary Analysis text by Herron and Freeman

53.  Swallow, J. G., T. Garland, Jr., P. A. Carter, W.-Z. Zhan, and G. C. Sieck. 1998.
        Effects of voluntary activity and genetic selection on aerobic capacity in house mice
        (Mus domesticus). Journal of Applied Physiology 84:69-76.   Abstract   [PDF file]
57.  Swallow, J. G., P. A. Carter, and T. Garland, Jr. 1998. Artificial selection for increased wheel-running
        behavior in house mice. Behavior Genetics 28:227-237.   Abstract   [PDF file]
58.  Krugner-Higby, L., A. Gendron, T. Garland, Jr., P. A. Carter, J. G. Swallow, and J. J. Lee. 1998.
        Eosinophylic polymyositis in a mouse.
       
Contemporary Topics in Laboratory Animal Science 37:94-97. [PDF file]
62.  Koteja, P., J. G. Swallow, P. A. Carter, and T. Garland, Jr. 1999. Energy cost of wheel running in
        house mice: implications for coadaptation of locomotion and energy budgets.
        Physiological and Biochemical Zoology 72:238-249  Abstract   [PDF file]
67.  Swallow, J. G., P. Koteja, P. A. Carter, T. Garland, Jr. 1999. Artificial selection for increased
        wheel-running activity in house mice results in decreased body mass at maturity.
        Journal of Experimental Biology 202:2513-2520.   Abstract   [PDF file]
68.  Koteja, P., T. Garland, Jr., J. K. Sax, J. G. Swallow, and P. A. Carter. 1999. Behaviour of house
        mice artificially selected for high levels of voluntary wheel running. Animal Behaviour 58:1307-1318.
        Abstract   [PDF file]
69.  Zhan, W.-Z., J. G. Swallow, T. Garland, Jr., D. N. Proctor, P. A. Carter, and G. C. Sieck. 1999.
        Effects of genetic selection and voluntary activity on the medial gastrocnemius muscle in
        house mice. Journal of Applied Physiology 87:2326-2333.   Abstract   [PDF file]
70.  Rhodes, J. S., P. Koteja, J. G. Swallow, P. A. Carter, and T. Garland, Jr. 2000. Body temperatures
        of house mice artificially selected for high voluntary wheel-running behavior: repeatability and effect
        of genetic selection. Journal of Thermal Biology 25:391-400.  Abstract   [PDF file]
71.  Carter, P. A., J. G. Swallow, Sarah J. Davis, and T. Garland, Jr. 2000. Nesting behavior of house mice
        (Mus domesticus) selected for increased wheel-running activity.
        Behavior Genetics 30:85-94.   Abstract   [PDF file]
74.  Houle-Leroy, P., T. Garland, Jr., J. G. Swallow, and H. Guderley. 2000. Effects of voluntary activity
        and genetic selection on muscle metabolic capacities in house mice Mus domesticus.
        Journal of Applied Physiology 89:1608-1616.  Abstract   [PDF file]
76.  Koteja, P., J. G. Swallow, P. A. Carter, and T. Garland, Jr. 2000. Individual variation
        and repeatability of maximum cold-induced energy assimilation in house mice.
        Acta Theriologica 45:455-470.   Abstract   [PDF file]
77.  Koteja, P., and T. Garland, Jr. 2001. Response to R. Eikelboom. Animal Behaviour 61:F25-F26.
       [PDF file]
       [Eikelboom, R. 2001. Bins, bouts and wheel running speed. Animal Behaviour 61:679-681.]
78.  Koteja, P., J. G. Swallow, P. A. Carter, and T. Garland, Jr. 2001. Maximum cold-induced food
       consumption in mice selected for high locomotor activity: implications for the evolution of endotherm
       energy budgets. Journal of Experimental Biology 204:1177-1190.  Abstract   [PDF file]
83.  Swallow, J. G., P. Koteja, P. A. Carter, and T. Garland, Jr. 2001. Food consumption and body
       composition in mice selected for high wheel-running activity.
       Journal of Comparative Physiology B 171:651-659.   Abstract   [PDF file]
       [Gee, Henry. 14 Sept. 1999. Lifelines: Running mice are leaner mice.
         Nature Science Updatehttp://www.nature.com/nsu/990916/990916-6.html]
84.  Dumke, C. L., J. S. Rhodes, T. Garland, Jr., E. Maslowski, J. G. Swallow, A.C. Wetter, and
       G. D. Cartee. 2001. Genetic selection of mice for high voluntary wheel-running: effect on skeletal
       muscle glucose uptake. Journal of Applied Physiology 91:1289-1297.   Abstract   [PDF file]
85.  Bronikowski, A. M., P. A. Carter, J. G. Swallow, I. A. Girard, J. S. Rhodes, and T. Garland, Jr.
       2001. Open-field behavior of house mice selectively bred for high voluntary wheel running.
       Behavior Genetics 31:309-316.  Abstract   [PDF file]
86.  Rhodes, J. S., G. R. Hosack, I. Girard, A. E. Kelley, G. S. Mitchell, and T. Garland, Jr. 2001.
       Differential sensitivity to acute administration of cocaine, GBR 12909, and fluoxetine in mice selectively
       bred for hyperactive wheel-running behavior. Psychopharmacology 158:120-131.  Abstract   [PDF file]
87.  Girard, I., M. W. McAleer, J. S. Rhodes, and T. Garland, Jr. 2001. Selection for high voluntary wheel
       running increases intermittency in house mice (Mus domesticus).   [PDF file]
       Journal of Experimental Biology 204:4311-4320.   Movie     See also "In this issue" pages i-ii.
90.  Garland, T., Jr. 2001. Phylogenetic comparison and artificial selection:  two approaches in
       evolutionary physiology. Pages 107-132 in R. C. Roach, P. D. Wagner, and P. H. Hackett, eds.
       Hypoxia: From Genes to the Bedside. Advances in Experimental Biology and Medicine, volume 502.
       Kluwer Academic/Plenum Publishers, New York.   [PDF file]
92.  Thomson, S. L., T. Garland, Jr., J. G. Swallow, and P. A. Carter. 2002. Response of Sod-2 enzyme
       activity to selection for high voluntary wheel running. Heredity 88:52-61.  Abstract   [PDF file]
93.  Girard, I., and T. Garland, Jr. 2002. Plasma corticosterone response to acute and chronic voluntary
       exercise in female house mice. Journal of Applied Physiology 92:1553-1561.   [PDF file]
94.  Girard, I., J. G. Swallow, P. A. Carter, P. Koteja, J. S. Rhodes, and T. Garland, Jr. 2002.
       Maternal-care behavior and life-history traits in house mice (Mus domesticus) artificially
       selected for high voluntary wheel-running activity. Behavioural Processes 57:37-50.  [PDF file]
95.  Garland, T., Jr. 2003. Selection experiments: an under-utilized tool in biomechanics and organismal
       biology. Pages 23-56 in V. L. Bels, J.-P. Gasc, and A. Casinos, eds. Vertebrate Biomechanics and
       Evolution. BIOS Scientific Publishers, Oxford, U.K.   [PDF file]
96.  Garland, T., Jr., M. T. Morgan, J. G. Swallow, J. S. Rhodes, I. Girard, J. G. Belter, and P. A. Carter.
       2002. Evolution of a small-muscle polymorphism in lines of house mice selected for high activity levels.
       Evolution 56:1267-1275.   [PDF file]
97.  Klomberg, K. L., T. Garland, Jr., J. G. Swallow, and P. A. Carter. 2002. Dominance, plasma testosterone
       levels, and testis size in mice artificially selected for high activity levels.
       Physiology & Behavior 77:27-38.   Abstract   [PDF file]
98.  Bronikowski, A. M., T. J. Morgan, T. Garland Jr., and P. A. Carter. 2002. Antioxidant gene expression
       in active and sedentary house house mice (Mus domesticus) selected for high voluntary wheel-running
       behavior. Genetics 161:1763-1769.  [PDF file]
102.  Houle-Leroy, P., T. Garland, Jr., J. G. Swallow, and H. Guderley. 2003. Artificial selection for high
         activity favors mighty mini-muscles in house mice. American Journal of Physiology
         Regulatory Integrative Comparative Physiology 284:R433-R443.   [PDF file]
103.  Morgan, T. J., T. Garland, Jr., and P. A. Carter. 2003. Ontogenies in mice selected for high voluntary
         wheel-running activity. I. Mean ontogenies. Evolution 57:646-657.   [PDF file]
104.  Bronikowski, A. M., P. A. Carter, T. J. Morgan, T. Garland, Jr., N. Ung, T. D. Pugh, R. Weindruch,
         and T. A. Prolla. 2003. Lifelong voluntary exercise in the mouse prevents age-related alterations in gene
         expression in the heart. Physiological Genomics 12:129-138.   [PDF file]
         [Welle, S., and S. B. Glueck. 2003. In for the long run: Focus on "Lifelong voluntary exercise in the mouse
           prevents age-related alterations in gene expression in the heart." Physiological Genomics 12:71-72.]
106.  Rhodes, J. S., and T. Garland, Jr. 2003. Differential sensitivity to acute administration of Ritalin,
         apomorphine, SCH 23390, and raclopride in mice selectively bred for hyperactive wheel-running behavior.
         Psychopharmacology 167:242-250.   [PDF file]
107.  Morgan, T. J., T. Garland, Jr., B. L. Irwin, J. G. Swallow, and P. A. Carter. 2003. The mode of evolution
         of molecular markers in populations of house mice under artificial selection for locomotor behavior.
         Journal of Heredity 94:236-242.   [PDF file]
109.  Rhodes, J. S., H. van Praag, S. Jeffrey, I. Girard, G. S. Mitchell, T. Garland, Jr., and F. H. Gage. 2003.
         Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning
         in mice bred for increased voluntary wheel running. Behavioral Neuroscience 117:1006-1016. [PDF file]
111.  Johnson, R. A., J. S. Rhodes, S. L. Jeffrey, T. Garland, Jr., and G. S. Mitchell. 2003. Hippocampal
         brain-derived neurotrophic factor but not neurotrophin-3 increases more in mice selected for
         increased voluntary wheel running. Neuroscience 121:1-7.  [PDF file]
113.  Hochstetler, K. J., T. Garland, Jr., J. G. Swallow, P. A. Carter, and A.Bult-Ito. 2004. Number of arginine-
         vasopressin neurons in the suprachiasmatic nuclei is not related to level or circadian characteristics of
         wheel-running activity in house mice. Behavior Genetics 34:131-136. [PDF file]
114.  Gammie, S. C., N. S. Hasen, J. S. Rhodes, I. Girard, and T. Garland, Jr. 2003. Predatory aggression, but not
         maternal or intermale aggression, is associated with high voluntary wheel-running behavior in mice.
         Hormones and Behavior  44:209-221. [PDF file]
116.  Rhodes, J. S., T. Garland, Jr., and S. C. Gammie. 2003. Patterns of brain activity associated with
         variation in voluntary wheel-running behavior. Behavioral Neuroscience 117:1243-1256.  [PDF file]
117.  Koteja, P., J. G. Swallow, P. A. Carter, and T. Garland, Jr. 2003. Different effects of intensity and
         duration of locomotor activity on circadian period. Journal of Biological Rhythms 18:491-501.
          [Abstract] [PDF file]
118.  Koteja, P., P. A. Carter, J. G. Swallow, and T. Garland, Jr. 2003. Food wasting in house mice:

         variation among individuals, families, and genetic lines. Physiology & Behavior 80:375-383. [PDF file]
121.  Belter, J. G., H. V. Carey, and T. Garland, Jr. 2004. Effects of voluntary exercise and genetic
         selection for high activity levels on HSP70 expression in house mice.
         Journal of Applied Physiology 96:1270-1276. [PDF file]
124.  Bronikowski, A. M., J. S. Rhodes, T. Garland, Jr., T. A. Prolla, T. Awad, and S. C. Gammie. 2004.
         The evolution of gene expression in the hippocampus in response to selective breeding for increased
         locomotor activity. Evolution 58:2079-2086. [PDF file]
127.  Li, G., J. S. Rhodes, I. Girard, S. C. Gammie, and T. Garland, Jr. 2004. Opioid-mediated pain
         sensitivity in mice bred for high voluntary wheel running. Physiology & Behavior 83:515-524. [PDF file]
129.  Morgan, T. J., M. A. Evans, T. Garland, Jr., J. G. Swallow, and P. A. Carter. 2005.
         Molecular and quantitative genetic divergence among populations of house mice with known
         evolutionary histories. Heredity 94:518-525.  [PDF file]
130.  Swallow, J. G., and T. Garland, Jr. 2005. Selection experiments as a tool in evolutionary and
         comparative physiology: insights into complex traits - An introduction to the symposium.
         Integrative and Comparative Biology 45:387-390.  [PDF file]
131.  Swallow, J. G., J. S. Rhodes, and T. Garland, Jr. 2005. Phenotypic and evolutionary plasticity of
         organ masses in response to voluntary exercise in house mice. Integrative and Comparative Biology
         45:426-437.  [PDF file]
132.  Rhodes, J. S., S. C. Gammie, and T. Garland, Jr. 2005. Neurobiology of mice selected for high
         voluntary wheel-running activity. Integrative and Comparative Biology 45:438-455.  [PDF file]
133.  Rezende, E. L., M. A. Chappell, F. R. Gomes, J. L. Malisch, and T. Garland, Jr. 2005. Maximal
         metabolic rates during voluntary exercise, forced exercise, and cold exposure in house mice selectively
         bred for high wheel-running. Journal of Experimental Biology 208:2447-2458.  [PDF file]
135.  Syme, D. A., K. Evashuk, B. Grintuch, E. L. Rezende, and T. Garland, Jr. 2005. Contractile abilities
         of normal and “mini” triceps surae muscles from mice (Mus domesticus) selectively bred for high
         voluntary wheel running. Journal of Applied Physiology 99:1308-1316.  [PDF file]
136.  Garland, T., Jr., and P. A. Freeman. 2005. Selective breeding for high endurance running increases
         hindlimb symmetry. Evolution 59:1851-1854.  [PDF file]
137.  Rezende, E. L., S. A. Kelly, F. R. Gomes, M. A. Chappell, and T. Garland, Jr. 2006.
         Effects of size, sex, and voluntary running speeds on costs of locomotion in lines of laboratory mice
         selectively bred for high wheel-running activity. Physiological and Biochemical Zoology 79:83-99.
         [PDF file]
139.  Rezende, E. L., T. Garland, Jr., M. A. Chappell, J. L. Malisch, and F. R. Gomes. 2006.
         Maximum aerobic performance in lines of Mus selected for high wheel-running activity: effects of selection,
         oxygen availability, and the mini-muscle phenotype. Journal of Experimental Biology 209:115-127.  [PDF file]
141.  Kelly, S. A., P. P. Czech, J. T. Wight, K. M. Blank, and T. Garland, Jr. 2006.
         Experimental evolution and phenotypic plasticity of hindlimb bones in high-activity house mice.
         Journal of Morphology 267:360-374.
  [PDF file]
143.  Guderley, H., P. Houle-Leroy, G. M. Diffee, D. M. Camp, and T. Garland, Jr. 2006. Morphometry, ultrastructure,
         myosin isoforms, and metabolic capacities of the "mighty mini muscles" favoured by selection for high activity
         in house mice. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biol. 144:271-282.   [PDF file]
145.  Rezende, E. L., F. R. Gomes, J. L. Malisch, M. A. Chappell, and T. Garland, Jr. 2006. Maximal oxygen
         consumption in relation to subordinate traits in lines of house mice selectively bred for high voluntary
         wheel running. Journal of Applied Physiology 101:477-485.  [PDF file]
146.  Zhang, Y., T.-S. Lee, E. M. Kolb, K. Sun, X. Lu, F. M. Sladek, G. S. Kassab, T. Garland, Jr., and J. Y.-J. Shyy.
         2006. AMP-activated protein kinase is involved in endothelial nitric-oxide synthase activation in response
         to shear stress. Arteriosclerosis, Thrombosis, and Vascular Biology 26:1281-1287.  [PDF file]
         
Faculty of 1000 Selection!
147.  Bronikowski, A. M., T. Morgan, T. Garland, Jr., and P.A. Carter. 2006. The evolution
         of aging and age-related physical decline in mice selectively bred for high voluntary exercise.
         Evolution 60:1494-1508.  [PDF file]
148.  Garland, T., Jr., and S. A. Kelly. 2006. Phenotypic plasticity and experimental evolution.
        Journal of Experimental Biology 209:2344-2361.  [PDF file]

150.  Krugner-Higby, L., I. Girard, J. Welter, A. Gendron, J. S. Rhodes, and T. Garland Jr. 2006.
         Clostridial enteropathy in lactating outbred swiss-derived (ICR) mice.
         Journal of the American Association for Laboratory Animal Science 45:80-87.  [PDF file]
151.  Vaanholt, L. M., T. Garland Jr., S. Daan, and G. H. Visser. 2006. Wheel-running activity and energy metabolism
         in relation to ambient temperature in mice selected for high wheel-running activity.
         Journal of Comparative Physiology B 177:109-118.   [PDF file]
152.  Malisch, J. L., W. Saltzman, F. R. Gomes, E. L. Rezende, D. R. Jeske, and T. Garland, Jr. 2007.
         Baseline and stress-induced plasma corticosterone concentrations of mice selectively bred for high
         voluntary wheel running. Physiological and Biochemical Zoology 80:146-156.  [PDF file]
154.  Belke, T. W., and T. Garland, Jr. 2007. A brief opportunity to run does not function as a reinforcer for mice selected
         for high daily wheel-running rates. Journal of the Experimental Analysis of Behavior  88:199-213.  [PDF file]
155.  Vaanholt, L. M., P. Meerlo, T. Garland, Jr., G. H. Visser, and G. van Dijk. 2007. Plasma adiponectin is increased
         in mice selectively bred for high wheel-running activity, but not by wheel running per sé.
         Hormone and Metabolic Research 39:377-383.  [PDF file]

156.  Vaanholt, L. M., B. De Jong, T. Garland, Jr., S. Daan, and G. H. Visser. 2007. Behavioural and physiological
         responses to increased foraging effort in male mice. Journal of Experimental Biology 210:2013-2024.   [PDF file]

160.  Girard, I., E. L. Rezende, and T. Garland, Jr. 2007. Leptin levels and body composition of mice selectively
         bred for high voluntary activity. Physiological and Biochemical Zoology 80:568-579.   [PDF file]
162.  Middleton, K. M., C. E. Shubin, D. C. Moore, P. A. Carter, T. Garland, Jr., and S. M. Swartz. 2008.
         The relative importance of genetics and phenotypic plasticity in dictating bone morphology and mechanics
         in aged mice: evidence from an artificial selection experiment. Zoology 111:135-147. [PDF file]
163.  Vaanholt, L. M., J. R. Speakman, T. Garland Jr., G. E. Lobley, and G. H. Visser. 2008. Protein synthesis and
         antioxidant capacity in aging mice: effects of long-term voluntary exercise.
         Physiological and Biochemical Zoology 81:148-157.  [PDF file]
164.  Guderley, H., D. R. Joanisse, S. Mokas, G. M. Bilodeau, and T. Garland, Jr. 2008. Altered fiber types
         in gastrocnemius muscle of high wheel-running selected mice with mini muscle phenotypes.
         Comparative Biochemistry and Physiology, Part B 149:490-500.  [PDF file]
165.  Kane, S. L., T. Garland, Jr., and P. A. Carter. 2008. Basal metabolic rate of aged mice is affected by random
         genetic drift but not by selective breeding for high early-age locomotor activity or chronic wheel access.
         Physiological and Biochemical Zoology 81:288-300. [PDF_file]
166.  Hannon, R. M., S. A. Kelly, K. M. Middleton, E. M. Kolb, D. Pomp, and T. Garland, Jr. 2008.
         Phenotypic effects of the “mini-muscle” allele in a large HR x C57BL/6J mouse backcross.
         Journal of Heredity 99:349-354. [PDF file]
167.  Malisch, J. L., C. W. Breuner, F. R Gomes, M. A. Chappell, and T. Garland, Jr. 2008.
         Circadian pattern of total and free corticosterone concentrations, corticosteroid-binding globulin,
         and physical activity in mice selectively bred for high voluntary wheel-running behavior.
         General and Comparative Endocrinology 156:210-217. [PDF file]
169.  Hartmann, J., T. Garland, Jr., R. M. Hannon, S. A. Kelly, G. Muñoz, and D. Pomp. 2008. Fine mapping
         of "Mini-Muscle", a recessive mutation causing reduced hind-limb muscle mass in mice.
         Journal of Heredity 99:679-687. [PDF file]
171.  Middleton, K. M., S. A. Kelly, and T. Garland, Jr. 2008. Selective breeding as a tool to probe
         skeletal response to high voluntary locomotor activity in mice.
         Integrative and Comparative Biology 48:394-410. [PDF file]
172. Vaanholt, L. M., I. Jonas, M. Doornbos, K. A. Schubert, C. Nyakas, T. Garland, Jr., G. H. Visser,
         and Gertjan van Dijk. 2008. Responses in energy balance to high-fat feeding in mice selectively
         bred for high wheel-running activity. International Journal of Obesity 32:1566-1575. [PDF file]
173. Yan, R. H., J. L. Malisch, R. M. Hannon, P. L. Hurd, and T. Garland, Jr. 2008. Selective
         breeding for a behavioral trait changes digit ratio. PLoS ONE 3(9):e3216. doi:10.1371/journal.pone.0003216. [PDF file]
175. Keeney, B. K., D. A. Raichlen, T. H. Meek, R. S. Wijeratne, K. M. Middleton, G. L. Gerdeman,
         and T. Garland, Jr. 2008. Differential response to a selective cannabinoid
         receptor antagonist (SR141716: rimonabant) in female mice from lines selectively bred for high
         voluntary wheel-running behavior. Behavioural Pharmacology 19:812-820. [PDF file]
176. Malisch, J. L., S. A. Kelly, A. Bhanvadia, K. M. Blank, R. L. Marsik, E. G. Platzer, and T. Garland, Jr.
        2009. Lines of mice with chronically elevated baseline corticosterone are more
        susceptible to a parasitic nematode infection. Zoology 112:316-324. [PDF file]
177. Gomes, F. R., E. L. Rezende, J. L. Malisch, S. K. Lee, D. A. Rivas, S. A. Kelly, C. Lytle,
        B. B. Yaspelkis III, and T. Garland, Jr. 2009. Glycogen storage and muscle glucose transporters
        (GLUT-4) of mice selectively bred for high voluntary wheel running.
        Journal of Experimental Biology 212:238-248. [PDF file]

178. Malisch, J. L., C. W. Breuner, E. M. Kolb, H. Wada, R. M. Hannon, M. A. Chappell, K. M. Middleton,
        and T. Garland, Jr. 2009. Behavioral despair and home-cage activity in mice with chronically elevated
        baseline corticosterone concentrations. Behavior Genetics 39:192-201. [PDF file]
179. Bilodeau, G. M., H. Guderley, D. R. Joanisse, and T. Garland, Jr. 2009. Reduction of type IIb myosin and
        IIB fibers in tibialis anterior muscle of mini-muscle mice from high-activity lines.
        Journal of Experimental Zoology Part A: Ecological Genetics and Physiology 311A:189-198. [PDF file]
180. McGillivray, D. G., T. Garland, Jr., E. M. Dlugosz, M. A. Chappell, and D. A. Syme. 2009.
        Changes in efficiency and myosin expression in the small-muscle phenotype of mice selectively bred
        for high voluntary running activity. Journal of Experimental Biology 212:977-985. [PDF file]
181. Young, N. M., B. Hallgrímsson, and T. Garland, Jr. 2009. Epigenetic effects on integration of limb lengths
        in a mouse model: selective breeding for high voluntary locomotor activity. Evolutionary Biology 36:88-99. [PDF file]
183. Nehrenberg, D. L., K. Hua, D. Estrada-Smith, T. Garland, Jr., and D. Pomp. 2009. Voluntary exercise and its
        effects on body composition depend on genetic selection history. Obesity 17:1402-1409. [PDF file]
184. Wong, L. E., T. Garland, Jr., S. Rowan, and R. T. Hepple. 2009. Anatomic capillarization is elevated in the
        medial gastrocnemius muscle of mighty mini mice. Journal of Applied Physiology 106:1660-1667.
[PDF file]
185. Eisenmann, J. C., E. E. Wickel, S. A. Kelly, K. M. Middleton, and T. Garland, Jr. 2009. Day-to-day variability
        in voluntary wheel running among genetically differentiated lines of mice that vary in activity level.
        European Journal of Applied Physiology 106:613-619. [PDF file]

188. Dlugosz, E. M., M. A. Chappell, D. G. McGillivray, D. A. Syme, and T. Garland, Jr. 2009. Locomotor
        trade-offs in mice selectively bred for high voluntary wheel running.
        Journal of Experimental Biology 212:2612-2618. [PDF file]
189. Meek, T. H., B. P. Lonquich, R. M. Hannon, and T. Garland, Jr. 2009. Endurance capacity of mice selectively
        bred for high voluntary wheel running. Journal of Experimental Biology 212: 2908-2917. [PDF file]
191.  Swallow, J. G., J. P. Hayes, P. Koteja, and T. Garland, Jr. 2009. Selection experiments and experimental
         evolution of performance and physiology. Pages 301-351 in Experimental Evolution: Concepts,
         Methods, and Applications of Selection Experiments, T. Garland, Jr., and M. R. Rose, eds.
         University of California Press, Berkeley, California. [PDF file]

192. Rezende, E. L., F. R. Gomes, M. A. Chappell, and T. Garland, Jr. 2009. Running behaviour and its energy
        cost in mice selectively bred for high voluntary locomotor activity.
        Physiological and Biochemical Zoology 82:662-679. [PDF file]
193. Nehrenberg, D. L., S. Wang, R. M. Hannon, T. Garland, Jr., and D. Pomp. 2010. QTL underlying voluntary
       
exercise in mice: interactions with the “mini muscle” locus and sex. Journal of Heredity 101:42-53. [PDF file]
195. Feder, M. E., T. Garland, Jr., J. H. Marden, and A. J. Zera. 2010. Locomotion in response to shifting climate
        zones: not so fast. Annual Review of Physiology 72:167-190. [PDF file] (includes review of rodent selection experiments)
196. Vaanholt, L. M., S. Daan,T. Garland, Jr., and G. H. Visser. 2010. Exercising for life? Energy metabolism,
        body composition, and longevity in mice exercising at different intensities.
        Physiological and Biochemical Zoology 83:239-251. [PDF file]

198. Kolb, E. M., S. A. Kelly, K. M. Middleton, L. S. Sermsakdi, M. A. Chappell, and T. Garland, Jr. 2010. Erythropoietin
        elevates VO2,max but not voluntary wheel running in mice. Journal of Experimental Biology 213:510-519. [PDF file]

200. Middleton, K. M., T. Garland, Jr., B. D. Goldstein, P. R. Guduru, S. A. Kelly, and S. M. Swartz. 2010.
        Variation in within-bone stiffness measured by nanoindentation in mice bred for high levels of
        voluntary wheel running. Journal of Anatomy 216:121-131.
[PDF file]
201. Kelly, S. A., D. L. Nehrenberg, K. Hua, R. R. Gordon, T. Garland, Jr., and D. Pomp. 2010. Parent-of-origin
        effects on voluntary exercise levels and body composition in mice. Physiological Genomics 40:111-120. [PDF file]
202. Meek, T. H., J. C. Eisenmann, and T. Garland, Jr. 2010. Western diet increases wheel running in mice
        selectively bred for high voluntary wheel running. International Journal of Obesity 34:960-969. [PDF file]

203. Jonas, I., M. Doornbos, L. Vaanholt, T. Garland, Jr, A. J. W. Scheurink, C. Nyakas, and G. van Dijk. 2010.
        Effects of selective breeding for increased wheel running behavior on circadian timing of substrate
        oxidation and ingestive behavior. Physiology & Behavior 99:549-554. [PDF file]
204. Wallace, I. J., K. M. Middleton, S. Lublinsky, S. A. Kelly, S. Judex, T. Garland, Jr., and B. Demes. 2010.
        Functional significance of genetic variation underlying limb bone diaphyseal structure.
        American Journal of Physical Anthropology 143:21-30. [PDF file]

205. Mathes, W. F., D. L. Nehrenberg, R. Gordon, K. Hua, T. Garland, Jr., and D. Pomp. 2010.
        Dopaminergic dysregulation in mice selectively bred for excessive exercise or obesity.
        Behavioural Brain Research 210:155-163. [PDF file]

206. Jonas, I., K. A. Schubert, A. C. Reijne, J. Scholte, T. Garland, Jr., M. P. Gerkema, A. J. W. Scheurink, C. Nyakas,
        and G. van Dijk. 2010. Behavioral traits are affected by selective breeding for increased wheel-running
        behavior in mice. Behavior Genetics 40:542-550. [PDF file]
207. Kelly, S. A., D. L. Nehrenberg, J. L. Peirce, K. Hua, B. M. Steffy, T. Wiltshire, F. Pardo Manuel de Villena,
        T. Garland, Jr., and D. Pomp. 2010. Genetic architecture of voluntary exercise in an advanced intercross line of mice.
        Physiological Genomics 42:190-200.
[PDF file]
211. Garland, T., Jr., S. A. Kelly, J. L. Malisch, E. M. Kolb, R. M. Hannon, B. K. Keeney, S. L. Van Cleave,
        and K. M. Middleton. 2011. How to run far: Multiple solutions and sex-specific responses to selective
        breeding for high voluntary activity levels. Proceedings of the Royal Society B 278:574-581. [PDF file]
        UCR Press Release
        To see a video of Dr. Garland discussing the research, click here.
214. Hannon, R. M., T. H. Meek, W. Acosta, R. C. Maciel, H. Schutz, and T. Garland, Jr. 2011. Sex-specific heterosis
        in line crosses of mice selectively bred for high locomotor activity. Behavior Genetics 41:615-624. [PDF file]

215. Kelly, S. A., D. L. Nehrenberg, K. Hua, T. Garland, Jr., and D. Pomp. 2011. Exercise, weight loss, and
        changes in body composition in mice: phenotypic relationships and genetic architecture.
        Physiological Genomics 43:199-212. [PDF file]

220. Farber, C. R., S. A. Kelly, E. Baruch, D. Yu, K. Hua, D. L. Nehrenberg, F. Pardo-Manuel de Villena, R. J. Buus,
        T. Garland, Jr., and D. Pomp. 2011. Identification of quantitative trait loci influencing skeletal architecture in mice:
        emergence of Cdh11 as a primary candidate gene regulating femoral morphology.
        Journal of Bone and Mineral Research 26:2174-2183. [PDF file]
222. Audet, G. N., T. H. Meek, T. Garland, Jr., and I. M. Olfert. 2011. Expression of angiogenic regulators and skeletal
        muscle capillarity in selectively bred high aerobic capacity mice. Experimental Physiology 96.11:1138-1150. [PDF file]
225. Wallace, I. J., S. M. Tommasini, S. Judex, T. Garland, Jr., and B. Demes. 2012. Genetic variations and physical
        activity as determinants of limb bone morphology: an experimental approach using a mouse model.
        American Journal of Physical Anthropology 148:24-35. [PDF file]
226. Downs, C. J., H. Schutz, T. H. Meek, E. M. Dlugosz, W. Acosta, K. S. de Wolski, J. L. Malisch, J. P. Hayes,
        and T. Garland, Jr. 2012. Within life-time trade-offs but evolutionary freedom for hormonal and immunological
        traits: evidence from mice bred for high voluntary exercise. Journal of Experimental Biology 215:1651-1661. [PDF file]
227. Meek, T. H., E. M. Dlugosz, K. T. Vu, and T. Garland, Jr. 2012. Effects of leptin treatment and Western diet
        on wheel running in selectively bred high runner mice. Physiology & Behavior 106:252-258. [PDF file]
228. Keeney, B. K., T. H. Meek, K. M. Middleton, L. F. Holness, and T. Garland, Jr. 2012. Sex differences in
        cannabinoid receptor-1 (CB1) pharmacology in mice selectively bred for high voluntary wheel-running behavior.
        Pharmacology, Biochemistry and Behavior 101:528-537. [PDF file]
229. Kelly, S. A., D. L. Nehrenberg, K. Hua, T. Garland, Jr., and D. Pomp. 2012. Functional genomic architecture of
        predisposition to voluntary exercise in mice: expression QTL in the brain. Genetics 191:643-654. [PDF file]
232. Careau, V. C., O. R. P. Bininda-Emonds, G. Ordonez, and T. Garland, Jr. 2012. Are voluntary wheel running
        and open-field behavior correlated in mice? Different answers from comparative and artificial selection approaches.
        Behavior Genetics 42:830-844. [PDF file]
233. Templeman, N. M., H. Schutz, T. Garland, Jr., and G. B. McClelland. 2012. Do mice bred selectively for high
        locomotor activity have a greater reliance on lipids to power submaximal aerobic exercise?
        American Journal of Physiology Regulatory Integrative and Comparative Physiology 303:R101-R111. [PDF file]
236. Kolb, E. M., E. L. Rezende, L. Holness, A. Radtke, S. K. Lee, A. Obenaus, and T. Garland, Jr. 2013.
        Mice selectively bred for high voluntary wheel running have larger midbrains: support for the mosaic
        model of brain evolution. Journal of Experimental Biology 216:515-523. [PDF file]
        [UCR Today] [Science Daily news story] [Deccan Herald] [NBC Los Angeles] [Animal Abstracts]
        [Medical News Today] [Many Years Young] [Indian Express] [moneycontrol.com] [Business Standard]
237. Waters, R. P., R. B. Pringle, G. L. Forster, K. J. Renner, J. L. Malisch, T. Garland, Jr., and J. G. Swallow. 2013.
        Selection for increased voluntary wheel-running affects behavior and brain monoamines in mice.
        Brain Research 1508:9-22. [PDF file]
238. Burniston, J. G., T. H. Meek, S. N. Pandey, G. Broitman-Maduro, M. F. Maduro, A. M. Bronikowski,
        T. Garland, Jr., and Y.-W. Chen. 2013. Gene expression profiling of gastrocnemius of "minimuscle" mice.
        Physiological Genomics 45:228-236. [PDF file]
239. Kolb, E. M., S. A. Kelly, and T. Garland, Jr. 2013. Mice from lines selectively bred for high voluntary
        wheel running exhibit lower blood pressure during withdrawal from wheel access.
        Physiology & Behavior 112-113:49-55. [PDF file]
240. Careau, V., M. E. Wolak, P. A. Carter, and T. Garland, Jr. 2013. Limits to behavioral evolution:
        the quantitative genetics of a complex trait under directional selection. Evolution 67:3102-3119. [PDF file]
242. Dlugosz, E. M., H. Schutz, T. H. Meek, W. Acosta, C. J. Downs, E. G. Platzer, M. A. Chappell, and T. Garland, Jr.
        2013. Immune response to a Trichinella spiralis infection in house mice from lines selectively bred for high
        voluntary wheel running. Journal of Experimental Biology 216:4212-4221. [PDF file]
244. Kelly, S. A., T. A. Bell, S. R. Selitsky, R. J. Buus, K. Hua, G. M. Weinstock, T. Garland, Jr.,
         F. Pardo-Manuel de Villena, and D. Pomp. 2014. A novel intronic SNP in the Myosin heavy polypeptide
         4
gene is responsible for the Mini-Muscle phenotype characterized by major reduction in hindlimb muscle
         mass in mice. Genetics 195:1385-1395. [PDF file]

246.  Meek, T. H., J. C. Eisenmann, B. K. Keeney, R. M. Hannon, E. M. Dlugosz, and T. Garland, Jr. 2014.
         Effects of early- life exposure to Western diet and wheel access on Metabolic Syndrome profiles in mice
         bred for high voluntary exercise. Genes, Brain and Behavior 13:322-332. [PDF file]  
247.  Guidotti, S., I. Jonas, K. M. Schubert, T. Garland, Jr., H. A. J.  Meijer, A. J. W. Scheurink, and G van Dijk. 2014.
         High-saturated fat-sucrose feeding affects lactation energetics in control mice and mice selectively bred for high
         wheel-running behavior.  American Journal of Physiology-Regulatory, Comparative and Integrative Physiology.
         305:R1433-440. [PDF File
248.  Kelly, S. A., E. L. Rezende, M. A. Chappell, F. R. Gomes, E. M. Kolb, J. L. Malisch, J. S. Rhodes, G. S. Mitchell,
         and T. Garland, Jr. 2014. Exercise training effects on hypoxic and hypercapnic ventilatory responses in mice selected
         for increased voluntary wheel running. Experimental Physiology 99:403-413. [PDF file]
251. Radojcic, T., and T. Garland, Jr. 2014. Born to run: Experimental evolution of high voluntary exercise in mice.
        Science Scope. In press. [PDF File] This is about the active-learning, middle-school lesson plan.

Table of Contents for:
Garland, T., Jr., and M. R. Rose, eds. 2009. Experimental evolution: concepts, methods, and applications
    of selection experiments. University of California Press, Berkeley, California.
PDF copies of the individual chapters can be obtained from the individual authors or from me.

 

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Last Updated 7March 2014 by T.G.